Aspirin Pre–Cardiac Surgery Benefits Chronic Kidney Patients
Category: Personal Health
Author: Georgina Tyburski
Posted: Friday - August 14, 2015
From anesthesiologynews.com
NEW ORLEANS—Preoperative aspirin administration decreases postoperative acute kidney injury and mortality in patients with chronic kidney disease undergoing cardiac surgery, a study finds.
“In previous studies, we found that aspirin pretreatment before surgery reduces perioperative complications and mortality in patients undergoing cardiac surgery,” said Jian-Zhong Sun, MD, PhD, professor of anesthesiology at Thomas Jefferson University, in Philadelphia. “Generally speaking, aspirin works for surgical patients presenting with high cardiovascular risk, but whether aspirin also provides the same protection for patients with chronic kidney disease is not clear.”
To address this question, Dr. Sun and his colleagues examined the records of 5,175 consecutive patients undergoing cardiac surgery in two tertiary care hospitals; 3,585 met inclusion criteria. These individuals were divided into two groups: those who did or did not take aspirin within five days of surgery. Baseline estimated glomerular filtration rate (eGFR, mL/min/1.73 m2) was classified as normal, greater than 90; mildly decreased, 60 to 89; moderately decreased, 30 to 59; severely decreased, 15 to 29; or kidney failure, less than 15. Chronic kidney disease was defined as eGFR less than 60 mL/min/1.73 m2. Postoperative acute kidney injury was defined by Acute Kidney Injury Network criteria (Crit Care 2007;11:R31). Major outcomes included acute kidney injury, length of ICU stay, readmission, major adverse cardiovascular events and 30-day mortality.
